{"id":62,"date":"2020-03-24T17:55:59","date_gmt":"2020-03-24T20:55:59","guid":{"rendered":"http:\/\/template1.bs2.com.br\/profissionais-saude\/?p=62"},"modified":"2020-03-24T17:56:01","modified_gmt":"2020-03-24T20:56:01","slug":"creatinofosfoquinase-cpk","status":"publish","type":"post","link":"https:\/\/www.prcardio.org\/profissionais-saude\/creatinofosfoquinase-cpk\/","title":{"rendered":"Creatinofosfoquinase (CPK)"},"content":{"rendered":"<!--themify_builder_content-->\n<div id=\"themify_builder_content-62\" data-postid=\"62\" class=\"themify_builder_content themify_builder_content-62 themify_builder tf_clear\">\n    <\/div>\n<!--\/themify_builder_content-->\n\n\n<h4 class=\"wp-block-heading\">Metabolismo<\/h4>\n\n\n\n<p>A creatinofosfoquinase (CPK) \u00e9 uma enzima que desempenha um importante papel regulador no metabolismo dos tecidos contr\u00e1teis. Est\u00e1 presente principalmente nos m\u00fasculos, tecido card\u00edaco e no c\u00e9rebro. Na eletroforese, podem ser identificadas tr\u00eas isoenzimas: CPK-BB \u00e9 a forma encontrada no c\u00e9rebro; a CPK-MB \u00e9 forma encontrada no mioc\u00e1rdio (m\u00fasculo card\u00edaco), e a CPK-MM \u00e9 forma encontrada no m\u00fasculo estriado.<\/p>\n\n\n\n<p>As duas maiores variantes conhecidas s\u00e3o denominadas macro-CPK, tipos 1 e 2. A macro-CPK do tipo 1&nbsp;\u00e9 comumente observada em idosos, especialmente em mulheres. A do tipo 2 est\u00e1 presente em pacientes que apresentam um quadro de met\u00e1stases tumorais ou outras enfermidades de alta gravidade. A macro-CPK&nbsp;pode interferir na an\u00e1lise&nbsp;da CPK-MB, elevando os seus n\u00edveis.<\/p>\n\n\n\n<p>A&nbsp;maior utiliza\u00e7\u00e3o da dosagem da CPK est\u00e1 no diagn\u00f3stico das les\u00f5es e doen\u00e7as da musculatura esquel\u00e9tica e no infarto do mioc\u00e1rdio (ataque card\u00edaco).<\/p>\n\n\n\n<p><strong>Causas de eleva\u00e7\u00e3o dos n\u00edveis de CPK<\/strong><\/p>\n\n\n\n<p>A CPK encontra-se marcadamente elevada na distrofia muscular de Duchenne, com eleva\u00e7\u00f5es que variam de 20 a 200 vezes o limite superior da normalidade, exerc\u00edcios extenuantes, polimiosite, dermatomiosites, miosites, miocardites, traumas musculares, inje\u00e7\u00f5es intramusculares recentes e ap\u00f3s crises convulsivas. Valores muito elevados s\u00e3o encontrados tamb\u00e9m nas rabdomi\u00f3lises, inclusive nas que t\u00eam como causa a intoxica\u00e7\u00e3o por uso de coca\u00edna.<\/p>\n\n\n\n<p>Tamb\u00e9m pode mostrar-se elevada em outras situa\u00e7\u00f5es como acidente vascular cerebral, embolia, infarto e edema pulmonar, ap\u00f3s cardiovers\u00e3o el\u00e9trica com m\u00faltiplos choques, tosse grave, trabalho de parto, nos quadros de mixedema (hipotireoidismo), na s\u00edndrome de hipertermia maligna, nas neoplasias de mama, pr\u00f3stata e trato gastrointestinal, em outras neoplasias em estado avan\u00e7ado, no per\u00edodo p\u00f3s-operat\u00f3rio imediato e na ingest\u00e3o de grandes quantidades de bebida alc\u00f3olica. Certos medicamentos, como as vastatinas e os fibratos (usados para tratar as anormalidades do colesterol e suas fra\u00e7\u00f5es), podem elevar a CPK total.<\/p>\n\n\n\n<p>Com o objetivo diagnosticar o infarto do mioc\u00e1rdio, solicita-se a dosagem da CPK-MB (avaliada pelo m\u00e9todo massa), a qual aumenta nas primeiras 4 a 6 horas ap\u00f3s o in\u00edcio do quadro, apresentando um pico entre 18 a 24 horas e permanecendo alterada por 48 a 72 horas ap\u00f3s o epis\u00f3dio. O aumento dos valores da CPK-MB no infarto do mioc\u00e1rdio depender\u00e3o da localiza\u00e7\u00e3o e da extens\u00e3o da \u00e1rea do cora\u00e7\u00e3o afetada.<\/p>\n\n\n\n<p><strong>Causas de redu\u00e7\u00e3o dos n\u00edveis de CPK<\/strong><\/p>\n\n\n\n<p>Seus n\u00edveis s\u00e9ricos podem estar diminu\u00eddos em situa\u00e7\u00f5es nas quais ocorra perda de massa muscular, nas hepatopatias alco\u00f3licas, na&nbsp;gravidez ect\u00f3pica, nas doen\u00e7as do tecido conjuntivo, na artrite reumatoide, em pacientes idosos e acamados e na terapia com esteroides. O repouso noturno diminui em 10 a 20% os n\u00edveis de CPK.<\/p>","protected":false},"excerpt":{"rendered":"<p>Metabolismo A creatinofosfoquinase (CPK) \u00e9 uma enzima que desempenha um importante papel regulador no metabolismo dos tecidos contr\u00e1teis. Est\u00e1 presente principalmente nos m\u00fasculos, tecido card\u00edaco e no c\u00e9rebro. Na eletroforese, podem ser identificadas tr\u00eas isoenzimas: CPK-BB \u00e9 a forma encontrada no c\u00e9rebro; a CPK-MB \u00e9 forma encontrada no mioc\u00e1rdio (m\u00fasculo card\u00edaco), e a CPK-MM \u00e9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-62","post","type-post","status-publish","format-standard","hentry","category-estudo-clinico","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SPC - Sociedade Paranaense de Cardiologia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.prcardio.org\/profissionais-saude\/creatinofosfoquinase-cpk\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SPC - Sociedade Paranaense de Cardiologia\" \/>\n<meta property=\"og:description\" content=\"Metabolismo A creatinofosfoquinase (CPK) \u00e9 uma enzima que desempenha um importante papel regulador no metabolismo dos tecidos contr\u00e1teis. Est\u00e1 presente principalmente nos m\u00fasculos, tecido card\u00edaco e no c\u00e9rebro. Na eletroforese, podem ser identificadas tr\u00eas isoenzimas: CPK-BB \u00e9 a forma encontrada no c\u00e9rebro; a CPK-MB \u00e9 forma encontrada no mioc\u00e1rdio (m\u00fasculo card\u00edaco), e a CPK-MM \u00e9 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.prcardio.org\/profissionais-saude\/creatinofosfoquinase-cpk\/\" \/>\n<meta property=\"og:site_name\" content=\"SPC - Sociedade Paranaense de Cardiologia\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-24T20:55:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-03-24T20:56:01+00:00\" \/>\n<meta name=\"author\" content=\"Hospedagem\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Hospedagem\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/creatinofosfoquinase-cpk\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/creatinofosfoquinase-cpk\\\/\"},\"author\":{\"name\":\"Hospedagem\",\"@id\":\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/#\\\/schema\\\/person\\\/a9b1dff39e9c1d3ba41de0f3dd6e1104\"},\"headline\":\"Creatinofosfoquinase (CPK)\",\"datePublished\":\"2020-03-24T20:55:59+00:00\",\"dateModified\":\"2020-03-24T20:56:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/creatinofosfoquinase-cpk\\\/\"},\"wordCount\":481,\"commentCount\":0,\"articleSection\":[\"Estudo Clinico\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/creatinofosfoquinase-cpk\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/creatinofosfoquinase-cpk\\\/\",\"url\":\"https:\\\/\\\/www.prcardio.org\\\/profissionais-saude\\\/creatinofosfoquinase-cpk\\\/\",\"name\":\"SPC - 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